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Natalizumab, an anti-4-integrin antibody that blocks leukocyte migration to the brain, is also currently under clinical investigation for drug-resistant epilepsy, with some successful cases reported in Rasmussens encephalitis [360, 361]

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103,104,105 The bioactive form of vitamin D (1,25(OH)2D3) also promotes the translocation of -catenin from the nucleus to the plasma membrane, represses -catenin-TCF-4 transcriptional activity, and finally activates the transcription of the DICKKOPF-1 gene, which encodes an extracellular Wnt inhibitor

Cuando estas cascadas se combinan con multiplicadores progresivos, cada reaccin puede elevar el potencial de la ronda

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